Exercise and GLUT4
Marcelo Flores‐Opazo, Sean L. McGee, Mark Hargreaves
Abstract
The glucose transporter GLUT4 is critical for skeletal muscle glucose uptake in response to insulin and muscle contraction/exercise. Exercise increases GLUT4 translocation to the sarcolemma and t-tubule and, over the longer term, total GLUT4 protein content. Here, we review key aspects of GLUT4 biology in relation to exercise, with a focus on exercise-induced GLUT4 translocation, postexercise metabolism and muscle insulin sensitivity, and exercise effects on GLUT4 expression.
Topics & Concepts
GLUT4SarcolemmaGlucose transporterSkeletal muscleInternal medicineEndocrinologyGlucose uptakeInsulin resistanceExercise physiologyInsulinMedicineChemistryBiologyMetabolism, Diabetes, and CancerAdipose Tissue and MetabolismCancer, Hypoxia, and Metabolism