Substitution controlled aryne insertion: synthesis of diarylmethane/chromones
Jadhav Rahul Dhanaji, Polasani Samatha, Silver Raju, Prathama S. Mainkar, Raju Adepu, S. Chandrasekhar
Abstract
A cascade double aryne insertion reaction was developed to generate a library of diarylmethane scaffolds. Additionally, chromone products were observed in presence of an electronegative atom at the ortho position of aryne.
Topics & Concepts
AryneChromoneChemistryCascadeStereochemistryCombinatorial chemistryMedicinal chemistryChromatographyCyclization and Aryne ChemistryCatalytic Alkyne ReactionsChemical Reactions and Mechanisms