Litcius/Paper detail

Recent advances in catalytic asymmetric alkenyl C(sp<sup>2</sup>)–H bond functionalizations

Xiao‐Ju Si, Tian-Ci Wang, Teck‐Peng Loh, Mingzhu Lu

2025Chemical Science11 citationsDOIOpen Access PDF

Abstract

)-H bonds in recent years. The current review provides a concise overview of these impressive achievements in the realm of asymmetric alkenyl C-H functionalization reactions, with a particular emphasis on substrate scopes, limitations, mechanistic studies, as well as their applications in the precise synthesis of diversely functionalized chiral molecules. Challenges and future opportunities regarding this area of research are also discussed. Through this review, we aim to inspire continuous efforts toward further development of more practical and broadly applicable strategies to advance this burgeoning field.

Topics & Concepts

ChemistryCatalysisStereochemistryOrganic chemistryCatalytic C–H Functionalization MethodsAxial and Atropisomeric Chirality SynthesisSynthesis and Catalytic Reactions