LAMA4 upregulation is associated with high liver metastasis potential and poor survival outcome of Pancreatic Cancer
Biao Zheng, Jianhua Qu, Kenoki Ohuchida, Haimin Feng, Stephen Jun Fei Chong, Zilong Yan, Yicui Piao, Peng Liu, Nan Sheng, Daiki Eguchi, Takao Ohtsuka, Kazuhiro Mizumoto, Zhong Liu, Shazib Pervaiz, Peng Gong, Masafumi Nakamura
Abstract
These data provide evidence for LAMA4 as a possible biomarker of disease progression and poor prognosis in pancreatic cancer. Our findings indicate that LAMA4 may contribute to pancreatic cancer metastasis via recruitment or activation of CAFs.
Topics & Concepts
Pancreatic cancerMetastasisCancer researchCancerDownregulation and upregulationBiologyMedicineOncologyInternal medicineGeneBiochemistryCell Adhesion Molecules ResearchCaveolin-1 and cellular processesPhagocytosis and Immune Regulation