SARS-CoV-2 suppression depending on the pH of graphene oxide nanosheets
Md. Saidul Islam, Masahiro Fukuda, Md Jakir Hossain, Nurun Nahar Rabin, Ryuta Tagawa, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Yoshihiro Sekine, Terumasa Ikeda, Shinya Hayami
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inactivation of pH-dependent graphene oxide (GO) nanosheets is presented. The observed virus inactivation using an authentic virus (Delta variant) and different GO dispersions at pH 3, 7, and 11 suggests that the higher pH of the GO dispersion yields a better performance compared to that of GO at neutral or lower pH. The current findings can be ascribed to the pH-driven functional group change and the overall charge of GO, favorable for the attachment between GO nanosheets and virus particles.
Topics & Concepts
GrapheneOxideDispersion (optics)Coronavirus disease 2019 (COVID-19)VirusSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)CoronavirusChemistryBiophysicsNanotechnologyChemical engineeringMaterials scienceVirologyBiologyMedicinePhysicsInternal medicineInfectious disease (medical specialty)EngineeringOpticsDiseaseOrganic chemistryGraphene and Nanomaterials ApplicationsSARS-CoV-2 detection and testingMembrane Separation Technologies