A novel substrate directed multicomponent reaction for the syntheses of tetrahydro-spiro[pyrazolo[4,3-<i>f</i>]quinoline]-8,5′-pyrimidines and tetrahydro-pyrazolo[4,3-<i>f</i>]pyrimido[4,5-<i>b</i>]quinolines <i>via</i> selective multiple C–C bond formation under metal-free conditions
Divyang M. Patel, Hetal J. Patel, Hetal J. Patel, José M. Padrón, Hitendra M. Patel, Hitendra M. Patel
Abstract
ethanol as a reaction medium and deep eutectic mixture as a catalyst) is demonstrated. Both approaches involve mild reaction conditions, use of non-hazardous solvents, and facilitate good to excellent reaction yields of the target compounds.
Topics & Concepts
QuinolineSubstrate (aquarium)ChemistryStereochemistryCombinatorial chemistryOrganic chemistryBiologyEcologyMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis and Biological Evaluation