Non-directed Pd-catalysed C–H arylation of [2.2]paracyclophane
Jun Pu, Lei Chen, Ruirui Wu, Peng Ye, Huan-Le Li, Shuang Wang, Zhen-Yuan Xu, Shao‐Jie Lou, Dan‐Qian Xu
Abstract
We report herein the palladium-catalysed mono-selective C-H arylation of [2.2]paracyclophane (PCP) with diverse aryl iodides in the absence of any pendant directing groups, providing straightforward and modular access to C4-arylated [2.2]paracyclophanes. Moreover, a new PCP-containing biaryl monophosphine complex could be readily obtained through further derivation of the arylated product.
Topics & Concepts
ChemistryPalladiumArylCombinatorial chemistryModular designProduct (mathematics)CatalysisStereochemistryOrganic chemistryComputer scienceMathematicsOperating systemGeometryAlkylCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsOrganoboron and organosilicon chemistry