Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
Chengsong Yan, Lin Zheng, Shutan Jiang, Haochen Yang, Jun Guo, Luyi Jiang, Tongzhou Li, Haosong Zhang, Yibing Bai, Yu Lou, Qi Zhang, Tingbo Liang, Wolfgang W. Schamel, Haopeng Wang, Weiwei Yang, Guangchuan Wang, Zheng‐Jiang Zhu, Bao‐Liang Song, Chenqi Xu
Topics & Concepts
Cytotoxic T cellLiver X receptorCholesterolTumor microenvironmentCancer researchBiologyT cellAutophagyCell biologyImmunologyImmune systemApoptosisEndocrinologyNuclear receptorBiochemistryGeneTranscription factorIn vitroImmune Cell Function and InteractionCancer Immunotherapy and BiomarkersT-cell and B-cell Immunology