Orf Virus ORF120 Protein Positively Regulates the NF-κB Pathway by Interacting with G3BP1
Yanlong Zhou, Jiyu Guan, Feng Gao, Zi Li, Yungang Lan, Huijun Lu, Deguang Song, Lijun Lv, Pin Lv, Mengshi Xu, Zhenzhen Wang, Hongbin He, Kui Zhao, Wenqi He
Abstract
As part of the host innate response, the nuclear factor-κB (NF-κB) pathway plays a partial antiviral role in nature by regulating the innate immune response. Thus, the NF-κB pathway is probably the most frequently targeted intracellular pathway for subversion by anti-immune modulators that are carried by a wide range of pathogens. Various viruses, including poxviruses, carry several proteins that prepare the host cell for viral replication by inhibiting cytoplasmic events, leading to the initiation of NF-κB transcriptional activity. However, NF-κB activity is hypothesized to facilitate viral replication to a great extent. The significance of our research is in the exploration of the activation mechanism of NF-κB induced by the Orf virus (ORFV) ORF120 protein interacting with G3BP1, which helps not only to explain the ability of ORFV to modulate the immune response through the positive regulation of NF-κB but also to show the mechanism by which the virus evades the host innate immune response.