Mitochondrial DNA targeting and impairment by a dinuclear Ir–Pt complex that overcomes cisplatin resistance
Cheng Zhang, Ruilin Guan, Xinxing Liao, Cheng Ouyang, Jiangping Liu, Liang‐Nian Ji, Hui Chao
Abstract
A dinuclear complex [(ppy)Ir(tpy)PtCl]<sup>2+</sup> (<bold>Ir–Pt</bold>) can exhibit strong antitumor activity towards cisplatin-resistant cancer cells and induce cell necrosis <italic>via</italic> mtDNA damage and mitochondrial dysfunction.
Topics & Concepts
CisplatinMitochondrial DNADNAMitochondrionChemistryDNA damageCancer researchMolecular biologyBiologyGeneticsBiochemistryChemotherapyGeneMetal complexes synthesis and propertiesMetal-Catalyzed Oxygenation MechanismsMagnetism in coordination complexes