Synthesis of polychloromethylated and halogenated spiro[5,5]trienones <i>via</i> dearomative spirocyclization of biaryl ynones
Junnan Li, Zi-Jie Li, Liu‐Yu Shen, Pinhua Li, Yicheng Zhang, Wenchao Yang
Abstract
A selective polychloromethylation and halogenation reaction of alkynes via a radical addition/spirocyclization cascade sequence was developed, in which applying polyhaloalkanes as the precursor of polyhalomethyl and halogen radicals.
Topics & Concepts
ChemistryCombinatorial chemistryMedicinal chemistryStereochemistryFluorine in Organic ChemistryOxidative Organic Chemistry ReactionsRadical Photochemical Reactions