Loss-of-Function Mutation in PTPN2 Causes Aberrant Activation of JAK Signaling Via STAT and Very Early Onset Intestinal Inflammation
Marianna Parlato, Qing Nian, Fabienne Charbit‐Henrion, Frank M. Ruemmele, Fernando Rodrigues‐Lima, Nadine Cerf–Bensussan, Bernadette Bègue, Jérémy Berthelet, Kaan Boztuǧ, Sylvain Latour, Rémi Duclaux‐Loras, Marco Maggioni, Emmanuel Martin, Thierry Jo Molina, Júlia Pázmándi, Frédéric Rieux‐Laucat
Topics & Concepts
statJAK-STAT signaling pathwayInflammationLoss functionMutationCancer researchFunction (biology)Signal transductionGain of functionBiologyImmunologyCell biologyGeneticsSTAT3GenePhenotypeTyrosine kinaseProtein Tyrosine PhosphatasesGalectins and Cancer BiologyRNA modifications and cancer