Disulfidptosis: a new form of programmed cell death
Tingjin Zheng, Qingbo Liu, Feiyue Xing, Chong Zeng, Weidong Wang
Abstract
Disulfidptosis, a new form of cell death triggered by disulfide stress, is characterized by the collapse of cytoskeleton proteins and F-actin due to the intracellular accumulation of disulfides. This discovery will eventually aid in the development of therapeutic strategies against cancer.
Topics & Concepts
IntracellularProgrammed cell deathCytoskeletonApoptosisCell biologyActinCellActin cytoskeletonChemistryDisulfide bondBiologyBiochemistryAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseasePhagocytosis and Immune Regulation