New ruthenium(<scp>ii</scp>) complexes with quinone diimine and substituted bipyridine as inert ligands: synthesis, characterization, mechanism of action, DNA/HSA binding affinity and cytotoxic activity
Milica Međedović, Ana Rilak Simović, Dušan Ćoćić, Laura Senft, Sanja Matić, Danijela Todorović, Suzana Popović, Dejan Baskić, Biljana Petrović
Abstract
). Moreover, these DNA/HSA experimental results were confirmed by molecular docking. Complexes 2, 5 and 6 exerted good to strong and highly selective cytotoxic activity against breast adenocarcinoma (MDA-MB 231), colorectal carcinoma (HCT116) and cervix adenocarcinoma (HeLa). Depending on their structure and cell line, the complexes acted differently in terms of their influence on autophagy, the cell cycle and the engaged apoptotic pathway.
Topics & Concepts
ChemistryRutheniumDenticityIntercalation (chemistry)Ethidium bromideStereochemistryBipyridineLigand (biochemistry)DiimineReactivity (psychology)TerpyridineMedicinal chemistryDNACrystallographyMetalInorganic chemistryOrganic chemistryCrystal structureCatalysisAlternative medicinePathologyBiochemistryReceptorMedicineMetal complexes synthesis and propertiesSynthesis and Biological EvaluationDNA and Nucleic Acid Chemistry