Pd(<scp>ii</scp>)-catalyzed <i>meta</i>-C–H bromination and chlorination of aniline and benzoic acid derivatives
Hao Wang, Lei Fu, Chunlin Zhou, Gang Li
Abstract
-C-H chlorination is also feasible under similar reaction conditions. The ease of the directing group removal and subsequent diverse transformations of the brominated products demonstrate the application potential of this method and promise new opportunities for drug discovery.
Topics & Concepts
HalogenationAnilineBenzoic acidCatalysisChemistryMedicinal chemistryOrganic chemistryCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsVanadium and Halogenation Chemistry