IGF2BP3-mediated regulation of <i>GLS</i> and <i>GLUD1</i> gene expression promotes treg-induced immune escape in human cervical cancer.
Tiantian Zhou, Ziyi Xiao, Lu Jin, Lihua Zhang, Le Bo, Jinhua Wang
Abstract
genes, key metabolic enzymes in glutamate and glutamine metabolism, through m6A modification. This process leads to immune escape in cervical cancer by promoting lactate production and secretion.
Topics & Concepts
GlutamineCervical cancerImmune systemCancer researchCancer cellCancerMedicineTranscriptomeBiomarkerGene expressionImmunologyBiologyGeneInternal medicineAmino acidBiochemistryRNA modifications and cancerCancer-related molecular mechanisms researchRNA Research and Splicing