A responsive cocktail nano-strategy breaking the immune excluded state enhances immunotherapy for triple negative breast cancer
Jingxian Yang, Mengyao Chen, Ruihao Li, Yanting Sun, Pingting Ye, Kang Fang, Chunhui Wang, Shuo Shi, Chunyan Dong
Abstract
generated by a photosensitizer (Ce6), the reactive oxygen species (ROS)-sensitive degradation of the nanocore ensured the site-directed release of Vad and BMS-1. The released Vad and damaged tumor DNA activated immune responses through the cGAS-STING pathway, while the elevated expression level of PD-L1 promoted the anti-tumor effect of BMS-1. Significant degradation of collagen fibers, restoration of immune effector cells, and lower tumor volume were observed in this integrated triple drug sequential therapy, which provides a promising prospect for TNBC treatment.
Topics & Concepts
ImmunotherapyImmune systemBreast cancerNano-Cancer immunotherapyCancerTriple-negative breast cancerMedicineCancer researchImmunologyInternal medicineMaterials scienceComposite materialNanoplatforms for cancer theranosticsImmunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers