Bimetallic metal–organic frameworks for tumor inhibition <i>via</i> combined photothermal-immunotherapy
Anning Li, Ning Wang, Yuxuan Song, Haifeng Sun, Jiwei Cui, Guiqiang Zhang, Qun Yu
Abstract
Herein, we report the design of therapeutic nanoparticles by encapsulating photosensitizers and aluminum ions into metal-organic frameworks. The nanoparticles could significantly inhibit the growth of primary and rechallenged tumors by a combination of photothermal therapy and immunotherapy. This work offers a promising strategy to design an immunologic nanoplatform for "cold" tumor therapy.
Topics & Concepts
Photothermal therapyBimetallic stripImmunotherapyNanoparticleMetal-organic frameworkCancer researchNanotechnologyMaterials scienceChemistryMedicineMetalCancerInternal medicineMetallurgyAdsorptionOrganic chemistryNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryImmunotherapy and Immune Responses