Inhibition of Escherichia coli Lipoprotein Diacylglyceryl Transferase Is Insensitive to Resistance Caused by Deletion of Braun’s Lipoprotein
Jingyu Diao, Rie Komura, Tatsuya Sano, Homer Pantua, Kelly M. Storek, Hiroko Inaba, Haruhiko Ogawa, Cameron L. Noland, Yutian Peng, Susan L. Gloor, Donghong Yan, Jing Kang, Anand Kumar Katakam, Michael Volný, Peter Liu, Nicholas N. Nickerson, Wendy Sandoval, Cary D. Austin, Jeremy Murray, Steven T. Rutherford, Mike Reichelt, Yiming Xu, Min Xu, Hayato Yanagida, Jun‐ichi Nishikawa, Patrick Reid, Christian N. Cunningham, Sharookh B. Kapadia
Abstract
As the emerging threat of multidrug-resistant (MDR) bacteria continues to increase, no new classes of antibiotics have been discovered in the last 50 years. While previous attempts to inhibit the lipoprotein biosynthetic (LspA) or transport (LolCDE) pathways have been made, most efforts have been hindered by the emergence of a common mechanism leading to resistance, namely, the deletion of the gene encoding a major Gram-negative outer membrane lipoprotein lpp .