A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release
Marisa M. Brockmann, Fereshteh Zarebidaki, Marcial Camacho, M. Katharina Grauel, Thorsten Trimbuch, Thomas C. Südhof, Christian Rosenmund
Abstract
-secretion coupling is mutually exclusive. Our results demonstrate that the functional interaction of RIM, RBP, and Munc13 is more profound than previously envisioned, acting as a functional trio that govern basic and short-term plasticity properties of neurotransmission.
Topics & Concepts
Active zoneNeurotransmitterChemistryCell biologyBiologyAnatomyBiophysicsBiochemistrySynaptic vesicleVesicleReceptorMembraneCellular transport and secretionLipid Membrane Structure and BehaviorRNA Interference and Gene Delivery