[153Sm]Samarium-labeled FAPI-46 radioligand therapy in a patient with lung metastases of a sarcoma
Clemens Kratochwil, Frederik L. Giesel, Hendrik Rathke, R Fink, Katharina Dendl, Jürgen Debus, Walter Mier, Dirk Jäger, Thomas Lindner, Uwe Haberkorn
Abstract
Fibroblast activation protein is overexpressed by cancerassociated fibroblasts (CAFs) in the stroma of several tumor entities and provides anti-immunogenic effects It can be targeted with radiolabeled small-molecule inhibitors (FAPIs)
Topics & Concepts
StromaMedicineSarcomaLungRectumPathologyRadiation therapyRadioligandCancer researchExternal beam radiotherapyNuclear medicineRadiologyInternal medicineBrachytherapyImmunohistochemistryReceptorPeptidase Inhibition and AnalysisProtease and Inhibitor MechanismsCardiac Structural Anomalies and Repair