Multicomponent Radical Cross‐Coupling Reaction of [1.1.1]Propellane: Synthesis of 1‐Arylthiol‐3‐Heteroaryl Bicyclo[1.1.1]pentanes †
Lin Li, Yumiao Liu, Jian Li, Qing Chen, Pengfei Zhang, Jiabin Shen, Jirong Wu
Abstract
Abstract Herein, a visible light‐mediated multicomponent radical cross‐coupling reaction of [1.1.1]propellane with N ‐heterocycles and disulfides is described. The mild conditions enabled the installation of the BCP motif in a wide variety of compounds in the absence of photocatalyst, additive and metal catalyst, with excellent functional group tolerance, This methodology opens a approach for the synthesis of potentially bioactive 1‐arylthiol‐3‐heteroaryl bicyclo[1.1.1]pentanes in moderate to good yield.
Topics & Concepts
PropellaneChemistryBicyclic moleculeYield (engineering)CatalysisCoupling reactionFunctional groupComputational chemistryBridged compoundsReaction conditionsCombinatorial chemistryPhotochemistryOrganic chemistryMaterials scienceMetallurgyPolymerSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods