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Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy

Yang Gao, Naoe Taira Nihira, Xia Bu, Chen Chu, Jinfang Zhang, Aleksandra Kołodziejczyk, Yizeng Fan, Ngai Ting Chan, Leina Ma, Jing Liu, Dong Wang, Xiaoming Dai, Huadong Liu, Masaya Ono, Akira Nakanishi, Hiroyuki Inuzuka, Brian J. North, Yu-Han Huang, Samanta Sharma, Yan Geng, Wei Xu, X. Shirley Liu, Lei Li, Yoshio Miki, Piotr Siciński, Gordon J. Freeman, Wenyi Wei

2020Nature Cell Biology394 citationsDOIOpen Access PDF

Topics & Concepts

Chromosomal translocationAcetylationCell biologyImmunotherapyChemistryCancer researchBiologyImmunologyBiochemistryImmune systemGeneCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionImmune cells in cancer
Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy | Litcius