Modern Kinetics and Mechanism of Protein Folding: A Retrospective
William A. Eaton
Abstract
-fold, as determined from single molecule fluorescence measurements. We also developed what has been called the "Hückel model" of protein folding, which quantitatively explains a wide range of equilibrium and kinetic measurements. This retrospective traces the history of contributions to the "fast folding" subfield from my lab until about 3 years ago, when I left protein folding to spend the rest of my research career trying to discover an inexpensive drug for treating sickle cell disease.
Topics & Concepts
Protein foldingNanosecondKineticsFolding (DSP implementation)ChemistryBiophysicsChemical physicsNanotechnologyCrystallographyPhysicsMaterials scienceLaserBiologyOpticsQuantum mechanicsEngineeringElectrical engineeringBiochemistryProtein Structure and DynamicsEnzyme Structure and FunctionHemoglobin structure and function