Integrated Analyses of the Gut Microbiota, Intestinal Permeability, and Serum Metabolome Phenotype in Rats with Alcohol Withdrawal Syndrome
Fan Yang, Wei Jidong, Mengke Shen, Yating Ding, Yufan Lu, Hafiz Muhammad Ishaq, Li Duan, Dong Yan, Qi Wang, Ruiling Zhang
Abstract
Gut microbiota dysbiosis is associated with certain psychiatric disorders through the "microbiota-gut-brain" axis. Here, we revealed that alcohol consumption induced colonic microbiota dysbiosis, increased intestinal permeability, and altered the serum metabolic phenotype in rats, and there was a strong correlation between gut microbiota dysbiosis and serum metabolite disorders. Thus, gut microbiota dysbiosis and serum metabolite alteration may be a cofactor for development of alcohol dependence.
Topics & Concepts
MetabolomeDysbiosisGut floraIntestinal permeabilityMetabolitePhenotypeBiologyGut–brain axisMetabolomicsImmunologyMicrobiologyEndocrinologyBioinformaticsGeneticsGeneDiet and metabolism studiesGut microbiota and healthTryptophan and brain disorders