Clobetasol propionate, a Nrf-2 inhibitor, sensitizes human lung cancer cells to radiation-induced killing via mitochondrial ROS-dependent ferroptosis
Archita Rai, Raghavendra S. Patwardhan, Sundarraj Jayakumar, Pradnya K. Pachpatil, Dhruv Das, Girish Ch. Panigrahi, Vikram Gota, Sejal Patwardhan, Santosh K. Sandur
Topics & Concepts
Lipid peroxidationReactive oxygen speciesOxidative stressA549 cellGlutathioneChemistryRadiosensitizerCancer researchGPX4RadioresistanceMitochondrionProgrammed cell deathCancer cellPharmacologyBiochemistryApoptosisCancerBiologyMedicineGlutathione peroxidaseRadiation therapySuperoxide dismutaseInternal medicineEnzymeFerroptosis and cancer prognosisCancer, Lipids, and MetabolismCancer-related molecular mechanisms research