Bone-Targeting AAV-Mediated Gene Silencing in Osteoclasts for Osteoporosis Therapy
Yeon-Suk Yang, Jun Xie, Sachin Chaugule, Dan Wang, Jung‐Min Kim, JiHea Kim, Phillip W.L. Tai, Seok Kyo Seo, Ellen M. Gravallese, Guangping Gao, Jae‐Hyuck Shim
Abstract
is a promising gene therapy that can preserve bone formation and mitigate osteoporosis, while limiting adverse off-target effects.
Topics & Concepts
OsteoclastCathepsin KGene silencingOsteolysisActivator (genetics)OsteoporosisCancer researchBone resorptionGenetic enhancementMedicineRANK LigandRANKLCell biologyReceptorInternal medicineChemistryBiologyGeneDentistryBiochemistryBone Metabolism and Diseasesinterferon and immune responsesRNA Research and Splicing