Thiazolidine-2,4-dione hybrids as dual alpha-amylase and alpha-glucosidase inhibitors: design, synthesis, <i>in vitro</i> and <i>in vivo</i> anti-diabetic evaluation
Gurpreet Singh, Rajveer Singh, Vikramdeep Monga, Sidharth Mehan
Abstract
antidiabetic assessment by the induction of diabetes in Wistar rats using streptozotocin. Molecule 9G has been identified as the most effective anti-diabetic molecule due to its ability to modulate several biochemical markers in blood plasma and tissue homogenates. The results were further confirmed by histology investigations conducted on isolated pancreas, liver, and kidney.
Topics & Concepts
In vitroThiazolidineAlpha-glucosidaseAlpha (finance)In vivoChemistryBiochemistryBiologyEnzymeBiotechnologyMedicineSurgeryPatient satisfactionConstruct validityClick Chemistry and ApplicationsBiochemical and Molecular ResearchEnzyme Production and Characterization