Peptide hydrogels as slow-release formulations of protein therapeutics: case study of asparaginase-loaded hydrogels
Huệ Thị Vũ, Evelien Peeters, Kenneth Hofkens, Katrien Vandemeulebroecke, Sara T’Sas, Charlotte Martin, Steven Ballet, Richard Hoogenboom, Steven Goossens, Tim Lammens, Maaike Van Trimpont, Annemieke Madder
Abstract
. Altogether, this study describes how peptide hydrogels can be exploited to provide injectable slow-release formulations of biologics, including enzyme therapeutics, to enhance their clinical applicability.
Topics & Concepts
Self-healing hydrogelsRandom hexamerChemistryPeptideBiophysicsBiochemistryPolymer chemistryBiologyGlycosylation and Glycoproteins ResearchEnzyme Production and CharacterizationMonoclonal and Polyclonal Antibodies Research