Selective brain entry of lipid nanoparticles in haemorrhagic stroke is linked to biphasic blood-brain barrier disruption
Zahraa S. Al-Ahmady, Ben Dickie, Isabelle Aldred, Dhifaf A. Jasim, Jack Barrington, Michael Haley, Eloïse Lemarchand, Graham Coutts, Satinderdeep Kaur, Jessica Bates, Sarah Curran, Ruth Goddard, Megan Walker, Adrian Parry‐Jones, Kostas Kostarelos, Stuart M. Allan
Abstract
Our findings suggest that selective accumulation of liposomes into the lesion site is linked to a biphasic pattern of BBB hyper-permeability. This approach provides a unique opportunity to selectively and efficiently deliver therapeutic molecules across the BBB, an approach that has not been utilised for haemorrhagic stroke therapy and is not achievable using free small drug molecules.
Topics & Concepts
Blood–brain barrierIn vivoStroke (engine)MedicinePathologyMRI contrast agentLiposomeEx vivoMagnetic resonance imagingPharmacologyChemistryIn vitroInternal medicineBiologyBiochemistryCentral nervous systemRadiologyBiotechnologyMechanical engineeringEngineeringBarrier Structure and Function StudiesIntracerebral and Subarachnoid Hemorrhage ResearchAcute Ischemic Stroke Management