Rh(III)‐Catalyzed C−H Activation/Annulation of <i>N</i>‐Methyl Arylhydrazines with Iodonium Ylides toward Ring‐fused Cinnolines
Changduo Pan, Cheng Yuan, Dongdong Chen, Yuefeng Chen, Jin‐Tao Yu
Abstract
Abstract The first Rh(III)‐catalyzed annulation of N‐methyl arylhydrazines with iodonium ylides was developed. This transformation undergoes cascade C−H activation/annulation, dehydration and demethylative aromatization under very simple reaction conditions, providing a series of oxycycloalkyl‐fused cinnolines in good yields.
Topics & Concepts
AnnulationChemistryAromatizationCatalysisRing (chemistry)Medicinal chemistryStereochemistryOrganic chemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsCatalytic Cross-Coupling Reactions