Silencing of miR-483-5p alleviates postmenopausal osteoporosis by targeting SATB2 and PI3K/AKT pathway
Fujiang Zhao, Yier Xu, Yulong Ouyang, Zhexu Wen, Guihao Zheng, Ting Wan, Guicai Sun
Abstract
experiments showed that miR-483-5p inhibitor significantly increased the bone mineral density and biomechanical parameters of femurs in ovariectomized (OVX) rats by targeting SATB2. In addition, the osteogenic differentiation and PI3K/AKT signaling were also regulated by miR-483-5p-SATB2 axis. Taken together, our findings indicated that miR-483-5p contributed to the pathogenesis of PMOP by inhibiting SATB2 and activating PI3K/AKT pathway. MiR-483-5p/SATB2 could be selected as a potential therapeutic target for PMOP.
Topics & Concepts
PI3K/AKT/mTOR pathwayProtein kinase BLY294002RUNX2Ovariectomized ratGene silencingOsteoporosisCancer researchChemistrySignal transductionMedicineEndocrinologyInternal medicineEstrogenGene expressionBiochemistryGeneBone Metabolism and DiseasesMicroRNA in disease regulationCancer-related molecular mechanisms research