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Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin

Ramy Ayoub, Rebecca M. Ruddy, Elizabeth Cox, Adeoye Oyefiade, Daniel Derkach, Suzanne Laughlin, Benjamin Ades‐Aron, Zahra Shirzadi, Els Fieremans, Bradley J. MacIntosh, Cynthia de Medeiros, Jovanka Skocic, Éric Bouffet, Freda D. Miller, Cindi M. Morshead, Donald Mabbott

2020Nature Medicine120 citationsDOIOpen Access PDF

Topics & Concepts

MedicinePlaceboDentate gyrusMetforminCrossover studyCognitionAdverse effectClinical trialNeurogenesisBrain Structure and FunctionOncologyInternal medicineHippocampusNeurosciencePsychologyPsychiatryPathologyAlternative medicineInsulinCancer-related cognitive impairment studiesChildhood Cancer Survivors' Quality of LifeNeurogenesis and neuroplasticity mechanisms
Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin | Litcius