Approach of a small protein to the biomimetic bis-(μ-oxo) dicopper active-site installed in MOF-808 pores with restricted access perturbs substrate selectivity of oxidase nanozyme
Rasmi V. Morajkar, Adarsh P. Fatrekar, Amit A. Vernekar
Abstract
), having dimensions larger than the pore aperture of MOF-808. This reaction lucidly produces water molecules as a result of four electron transfer to an oxygen molecule. Such unintended side reactivities warrant special attention as they can perturb redox processes and several cellular energy pathways. Through this study, we provide a close look at designing next-generation artificial enzymes that can address the complex challenges for their utility in advanced applications.
Topics & Concepts
SelectivitySubstrate (aquarium)AdamantaneActive siteChemistryCombinatorial chemistryOxidase testBiophysicsNanotechnologyMaterials scienceEnzymeBiochemistryOrganic chemistryBiologyCatalysisEcologyAdvanced Nanomaterials in CatalysisNanoplatforms for cancer theranosticsAdvanced biosensing and bioanalysis techniques