Protective effects of chlorogenic acid on trimethyltin chloride-induced neurobehavioral dysfunctions in mice relying on the gut microbiota
Yu Xi, He Li, Meihong Yu, Xuejie Li, Yan Li, Bowen Hui, Xiangquan Zeng, Jing Wang, Jian Li
Abstract
in TMT-treated mice. SCFAs, the gut microbial metabolites associated with neuroprotection, were increased in the mouse hippocampus following CGA treatment. TMT-induced neurotransmitter disorders were regulated by oral gavage of CGA, especially DL-kynurenine and acetylcholine chloride. Additionally, neurotransmitters in the mouse hippocampus were found to be highly associated with the gut microbiota. Our findings provided research evidence for the neuroprotective effect of CGA on TMT-induced neurobehavioral dysfunctions.
Topics & Concepts
NeuroprotectionNeurotoxicityNeuroinflammationPharmacologyGut floraHippocampal formationHippocampusNeurotransmitterChemistryMedicineEndocrinologyInternal medicineCentral nervous systemBiochemistryInflammationToxicityTryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments