Combined targeting of soluble latent TGF-ß and a solid tumor-associated antigen with adapter CAR T cells
Niels Werchau, Bettina Kotter, Elvira Criado-Moronati, Andre Gosselink, Nicole Cordes, Dominik Lock, Simon Lennartz, Carolin Kolbe, Nora Winter, Karin Teppert, Fabian Engert, Brian Webster, Joerg Mittelstaet, Daniel Schaefer, Peter Mallmann, Michael R. Mallmann, Dominik Ratiu, Mario Assenmacher, Thomas Schaser, Michael von Bergwelt‐Baildon, Pierre Abramowski, Andrew Kaiser
Abstract
. In sum, our study broadens the spectrum of targetable moieties for AdCAR T cells by soluble latent TGF-β.
Topics & Concepts
Tumor microenvironmentAntigenEffectorCancer researchIn vivoCytokineBiologyTransforming growth factorImmunologyChemistryCell biologyTumor cellsBiotechnologyCAR-T cell therapy researchImmunotherapy and Immune ResponsesImmune Cell Function and Interaction