Myeloid-specific deletion of ferroportin impairs macrophage bioenergetics but is disconnected from systemic insulin action in adult mice
Nathan C. Winn, Elysa W. Pierro, Matthew A. Cottam, Monica Bhanot, Alyssa H. Hasty
Abstract
We used myeloid-specific knockout of ferroportin to determine whether macrophage iron enrichment alters systemic metabolism. We found that macrophages in several tissues showed mitochondrial defects such as a reduction in mitochondrial reserve capacity. However, insulin action in the mice was preserved. These findings also suggest that Mɸs have a pronounced ability to withstand iron excess without evoking overt collateral damage and associated insulin resistance, which appears to be age dependent.
Topics & Concepts
FerroportinBioenergeticsInsulin resistanceMacrophageMyeloid cellsMyeloidInsulinBiologyKnockout mouseEndocrinologyInternal medicineCell biologyMetabolismImmunologyMitochondrionMedicineIron homeostasisGeneBiochemistryIn vitroIron Metabolism and DisordersTrace Elements in HealthHemoglobinopathies and Related Disorders