Design, synthesis, in vitro and in vivo evaluation against MRSA and molecular docking studies of novel pleuromutilin derivatives bearing 1, 3, 4-oxadiazole linker
Jie Liu, Guang‐Yu Zhang, Zhe Zhang, Bo Li, Fei Chai, Qi Wang, Zi‐Dan Zhou, Lingling Xu, Shou‐Kai Wang, Zhen Jin, You‐Zhi Tang
Topics & Concepts
ChemistryIn vivoAntibacterial activityStaphylococcus aureusDocking (animal)OxadiazoleIn vitroLinkerCombinatorial chemistryCytotoxicityStereochemistryBiochemistryBacteriaOrganic chemistryBiologyComputer scienceNursingBiotechnologyGeneticsOperating systemMedicineVeterinary medicine and infectious diseasesBioactive Compounds and Antitumor AgentsToxin Mechanisms and Immunotoxins