PDHA1-mediated H3K18 lactylation is involved in arsenic-induced nonalcoholic fatty liver disease by activating the CD36–NLRP3 inflammasome axis
Han Li, Zhenyang Li, Lin Chen, Xiaoshan Peng, Dapeng Wang, Qian Sun, Yuting Chen, Aihua Zhang, Qizhan Liu, Huanwen Tang
Topics & Concepts
Nonalcoholic fatty liver diseaseInflammasomeFatty liverLactate dehydrogenaseChemistryArsenicBiochemistryPyruvate dehydrogenase complexMetabolomicsPharmacologyLiver functionPyruvate dehydrogenase kinaseArsenic toxicityMetabolic pathwayLiver diseaseCoenzyme Q10Lipid metabolismMedicineLiver injuryBiologyOxidative phosphorylationThiamine pyrophosphateOxidative stressIn vivoMetabolismAlcoholic liver diseaseEndocrinologySteatosisInternal medicineFenofibrateArsenic contamination and mitigationRetinoids in leukemia and cellular processesPancreatitis Pathology and Treatment