Ten-year course of cognition in first-episode non-affective psychosis patients: PAFIP cohort
José Manuel Rodríguez-Sánchez, Esther Setién-Suero, Paula Suárez-Pinilla, Jaqueline Mayoral Van Son, Javier Vázquez-Bourgon, Patxi Gil López, Benedicto Crespo-Facorro, Rosa Ayesa-Arriola, PAFIP group
Abstract
BACKGROUND: A large body of research states that cognitive impairment in schizophrenia is static. Nevertheless, most previous studies lack a control group or have small study samples or short follow-up periods. METHOD: We aimed to address these limitations by studying a large epidemiological cohort of patients with first-episode schizophrenia spectrum disorders and a comparable control sample for a 10-year period. RESULTS: Our results support the generalized stability of cognitive functions in schizophrenia spectrum disorders considering the entire group. However, the existence of a subgroup of patients characterized by deteriorating cognition and worse long-term clinical outcomes must be noted. Nevertheless, it was not possible to identify concomitant factors or predictors of deterioration (all Ps > 0.05). CONCLUSIONS: Cognitive functions in schizophrenia spectrum disorder are stable; however, a subgroup of subjects that deteriorate can be characterized.