tRNA modifications tune m6A-dependent mRNA decay
Bastian Linder, Puneet Sharma, Jie Wu, Tosca Birbaumer, Cristián Eggers, Shino Murakami, R. Ott, Kai Fenzl, Hannah Vorgerd, Florian Erhard, Samie R. Jaffrey, Sebastian A. Leidel, Lars M. Steinmetz
Abstract
U-is associated with more aggressive tumors and poor prognosis. Overall, this pan-epitranscriptomic interaction represents a novel mechanism of post-transcriptional gene regulation with implications for human health.
Topics & Concepts
BiologyTranslation (biology)Transfer RNARibosomeMessenger RNARibosome biogenesisCell biologyRegulation of gene expressionGeneN6-MethyladenosineProtein biosynthesisGeneticsRNAMethyltransferaseMethylationRNA modifications and cancerRNA and protein synthesis mechanismsCancer-related gene regulation