Cross-Coupling of Ketone Enolates with Grignard and Zinc Reagents with First-Row Transition Metal Catalysts
Youssef Nassar, Fabien Rodier, Vincent Ferey, Janine Cossy
Abstract
The stereoselective transformation of ketones to substituted olefins has become of great importance in organic synthesis. This Review helps to define the scope and limitations of the first-row transition metal-catalyzed cross-couplings between various enolates and aryl, heteroaryl, alkenyl, alkynyl, and alkyl Grignard and zinc reagents.
Topics & Concepts
ReagentCatalysisZincChemistryArylKetoneTransition metalStereoselectivityAlkylOrganic chemistryGrignard reagentGrignard reactionCombinatorial chemistryOrganic synthesisCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis