Nanobubble-based anti-hepatocellular carcinoma therapy combining immune check inhibitors and sonodynamic therapy
Yun Liu, Shiqi Yang, Qing Zhou, Jun Zhou, Jinlin Li, Yao Ma, Bing Hu, Chaoqi Liu, Yun Zhao
Abstract
-NBs can induce ROS-dependent ICD to further boost anti-cancer immune responses under the action of targeting the PD-1/PD-L1 immune check point in the tumor microenvironment as a promising therapeutic agent for HCC.
Topics & Concepts
Sonodynamic therapyHepatocellular carcinomaMedicineImmune systemCancer researchOncologyPathologyImmunologyAlternative medicineNanoplatforms for cancer theranosticsGenetic and Kidney Cyst DiseasesExtracellular vesicles in disease