Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors
Chau Phi Dinh, Alexia Ville, Konstantin Neukirch, Guillaume Viault, Veronika Temml, Andreas Koeberle, Oliver Werz, Daniela Schuster, Hermann Stuppner, Pascal Richomme, Jean‐Jacques Hélesbeux, Denis Séraphin
Topics & Concepts
ChemistryArachidonate 5-lipoxygenaseAllosteric regulationLipoxygenaseArachidonic acidLipid signalingIC50BiochemistryStructure–activity relationshipRecombinant DNAEnzymeStereochemistryBiological activityIn vitroPharmacologyMedicineGeneBioactive Compounds and Antitumor AgentsNatural product bioactivities and synthesisPhytochemistry and Bioactive Compounds