Enterovirus Replication and Dissemination Are Differentially Controlled by Type I and III Interferons in the Gastrointestinal Tract
Alexandra I. Wells, Kalena A. Grimes, Carolyn B. Coyne
Abstract
mouse model of echovirus infection by the enteral route and define the differential roles of type I and III interferons (IFNs) in controlling viral replication in the intestine. These findings provide important insights into the mechanisms by which echoviruses infect the GI tract and the epithelium-specific antiviral pathways that control this infection.
Topics & Concepts
EchovirusEnterovirusVirologyBiologyIntestinal epitheliumGastrointestinal tractViral replicationGastrointestinal epitheliumEpitheliumImmunologyVirusGeneticsBiochemistryViral Infections and Immunology ResearchViral gastroenteritis research and epidemiologyCytomegalovirus and herpesvirus research