Multi-spectroscopic monitoring of molecular interactions between an amino acid-functionalized ionic liquid and potential anti-Alzheimer's drugs
Srishti Sharma, Manoj Kumar Banjare, Namrata Singh, Jan Korábečný, Kamil Kuča, Kallol K. Ghosh
Abstract
H-NMR experiments recorded deshielding for tacrine at relatively higher concentrations than PC-37. COSY investigations suggest that anti-Alzheimer's drugs after complexation with 4-PyC8 show a 1 : 1 ratio. The cross-peaks of the NOESY spectra involve correlations between anti-Alzheimer's drugs and AIL protons, indicating complexation between them. The observed results indicate that these complexes are expected to have a possible therapeutic role in reducing/inhibiting amyloid fibrils when incorporated into drug formulations.
Topics & Concepts
TacrineChemistryProton NMRvan der Waals forceFourier transform infrared spectroscopyFibrilStereochemistryBiophysicsMoleculeBiochemistryOrganic chemistryAcetylcholinesteraseEnzymeQuantum mechanicsBiologyPhysicsIonic liquids properties and applicationsCholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatments