Interplay Between Calcium and AMPK Signaling in Human Cytomegalovirus Infection
Diana M. Dunn, Joshua Munger
Abstract
Calcium signaling and the AMP-activated protein kinase (AMPK) signaling networks broadly regulate numerous aspects of cell biology. Human Cytomegalovirus (HCMV) infection has been found to actively manipulate the calcium-AMPK signaling axis to support infection. Many HCMV genes have been linked to modulating calcium signaling, and HCMV infection has been found to be reliant on calcium signaling and AMPK activation. Here, we focus on the cell biology of calcium and AMPK signaling and what is currently known about how HCMV modulates these pathways to support HCMV infection and potentially contribute to oncomodulation.
Topics & Concepts
AMPKSignal transductionCell biologyHuman cytomegalovirusProtein kinase ACalciumCalcium signalingBiologyAMP-activated protein kinaseCell signalingKinaseImmunologyMedicineVirusInternal medicineCytomegalovirus and herpesvirus researchCalcium signaling and nucleotide metabolismErythrocyte Function and Pathophysiology