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Sensitivity of the Elecsys Nucleocapsid Assay for the Detection of Preceding SARS-CoV-2 Infections

Brian Grunau, Janessa Tom, Michael Asamoah-Boaheng, Sheila F. O’Brien, Steven J. Drews, Sadaf Sediqi, Pascal M. Lavoie, Vilte Barakauskas, David A. Goldfarb

2022Open Forum Infectious Diseases15 citationsDOIOpen Access PDF

Abstract

Nucleocapsid serological assay sensitivity to identify severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections among vaccinees and for Omicron cases is unclear. In this prospective study, the Elecsys nucleocapsid assay was 89% sensitive in identifying SARS-CoV-2 infections 14-607 days pre-blood collection. Sensitivity was similar when comparing by vaccination status, and in Omicron (vs pre-Omicron) cases.

Topics & Concepts

MedicineVirologySensitivity (control systems)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakOutbreakInternal medicineInfectious disease (medical specialty)DiseaseElectronic engineeringEngineeringSARS-CoV-2 and COVID-19 ResearchSARS-CoV-2 detection and testingBiosensors and Analytical Detection
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