The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress
Hakjoo Lee, Sylvia B. Smith, Shey‐Shing Sheu, Yisang Yoon
Abstract
-induced mitochondrial permeability transition, suggesting that S-OPA1, and not L-OPA1, protects against cellular stress. Importantly, silencing of OMA1 expression increased oxidant-induced cell death, indicating that stress-induced OPA1 cleavage supports cell survival. Our findings suggest that S-OPA1 generation by OPA1 cleavage is a survival mechanism in stressed cells.
Topics & Concepts
Oxidative stressAtrophyBiologyCellOxidative phosphorylationCell survivalMedicineInternal medicineGeneticsApoptosisBiochemistryMitochondrial Function and PathologyNitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative Mechanisms