Litcius/Paper detail

GCN5–ERK lactylation–phosphorylation loop amplifies lactate-driven cancer progression

Bingsong Huang, Mingpeng Jin, Gaofeng Cui, Zhe WANG, Feng Wang, Mu Chen, Lei Zhu, Yunxuan Li, Xiaoning Yang, Rui Li, Jinhuan Wu, Linhui Zhai, Yiming He, Jie Yang, Xin Ding, Qianwen Wang, Zhen Xv, Yaobing Ouyang, Jiale Li, Yangbohui Yang, Ke Li, Zhenkun Lou, Georges Mer, Jing Zhang, Yuping Chen, Jian Yuan, Chunlong Zhong

2026Nature Chemical Biology8 citationsDOI

Topics & Concepts

MAPK/ERK pathwayWarburg effectPhosphorylationCancerCancer cellCancer researchCell biologyChemistryPeptideTumor progressionBiologyMAPK cascadeMechanism (biology)Downregulation and upregulationSignal transductionCancer therapyCancer treatmentMitogen-activated protein kinaseHEK 293 cellsEnzyme activatorCancer, Hypoxia, and MetabolismProteoglycans and glycosaminoglycans researchMelanoma and MAPK Pathways